Fig. 1

Flow of participants in pilot RCT. “Pre-eligible” refers to meeting eligibility criteria based on responses to the PSC survey conducted before the launch of the pilot RCT. “Engaged” refers to completion of the intervention counseling call. “Retained” refers to completion of the 6-month follow-up survey. SCCS Southern Community Cohort Study, PSC Precision Smoking Cessation, CPD cigarettes per day, PCP primary care provider, GBC Guideline-Based Care, MIC Metabolism-Informed Care, PRS Polygenic Risk Score